Mission and Milestones

John Friedman joins Board
Completed Phase 2A trial for SQ109
Raised $3.4 million in private capital
Infectex licenses SQ109 for Commercialization in Russia

Received $3.8 million NIH grant for C. difficile program

Manufactured clinical supply of SQ109
Thompson Reuters names SQ109 one of the most promising drugs
  entering phase 2

Awarded $600k grant from NIH for development of SQ109 in MDR TB
Completed Phase 1 trial for SQ109
Initiated Phase 2 trial for SQ109 in tuberculosis
$2.2 million in private capital raised

Received FDA Go-Ahead for Phase 2 trial of SQ109 in H. pylori-associated
  Duodenal Ulcer Disease in Company's Second IND

SQ109 Phase 1b clinical trial initiated
Awarded ARRA stimulus grant for finalization of manufacturing process for SQ109
Awarded $600k grant from NIH for investigation of SQ641 in non-TB indications
Raised $1.8M from equity sales in private placement financing

Awarded $2.3M grant from NIH for development of lead capuramycin drug candidate, SQ641
Raised $2.5M from equity sales in private placement financing

FDA grants Fast-Track designation to SQ109
SQ109 Phase 1a clinical trial completed
SQ109 receives European Union Orphan Product designation
TB STAT-PAK, a rapid lateral-flow serological test for TB for veterinary applications that Sequella licensed for Chembio Diagnostic Systems, is approved for marketing
U.S. Orphan Drug Status granted for SQ109
European Medicines Agency (EMEA) Orphan Drug Status granted for SQ109
Total Institutional and other investments including Maryland Department of Economic Development total $7.0M

Hires VP of Finance, Marty Zug, MBA
Hires Chief Medical Officer and Head Regulatory Affairs, Gary Horwith, M.D.
NIH grants exclusive world-wide commercialization license to Sequella for SQ109 and related compounds
Raises $4.1 million from equity sales in private placement financing
Files first Investigational New Drug (IND) application with U.S. FDA for new diamine antibiotic SQ109

Receives U.S. patent for TB Patch Diagnostic, and also granted nine ex-US country Patch patents
Receives U.S. patent for Therapeutic Diamine Anti-Infective Compounds(SQ109)
Raises $2.5 million in equity sales in private placement financing
Licenses out veterinary TB diagnostic to ChemBio, Inc.

Sankyo Co., Ltd. grants exclusive worldwide license to commercialize new antibiotics
Initiation of clinical trials in South Africa for Patch diagnostic using recombinant protein

Receives first (of 4) NIH Small Business Innovation Research Phase II grant ($1.0 million)
Receives first NIH U01 Biodefense Research grant ($1.6 million)
Hires EVP Business Development, Alan Klein, MBA

Receive support from NCI/NIAID for development of novel second-generation drugs for Tuberculosis

Awarded $1.2 million NIH Challenge Grant for discovery of new TB drugs
Japan BCG Laboratory grants exclusive world-wide license (excl. Japan) to diagnostic Patch Test for Active TB
Raises $400,000 in equity sales in private placement financing

Carol A. Nacy, Ph.D., named CEO
Awarded first NIH Small Business Innovation Research Phase I grant
Signed CRADA with NIH to discover new TB drugs

Hires first employee, Leo Einck, Ph.D., President
First Angel financing ($960,000)

Incorporation in Delaware
First sale of common stock, Founders ($560,000)